DESCRIPTION :-
Today we are going to look at the question paper of pharmaceutical organic chemistry. It is somewhat lengthy subject in third semester of Bachelor's in pharmacy. In pharmaceutical organic chemistry, must clear all of your concept because it contains too much conversion of compounds, naming reactions and preparations. It is also a interesting subject because there is no importance for cram.
III Semester Examination May 2019
BACHELOR OF PHARMACY
Pharmaceutical Organic Chemistry - 2
(BP-301T)
Time :- 3 hrs. Marks :- 80
Answer any FIVE questions :-
1. a) What is Aromaticity? Which of the following compounds are aromatic? (4)
b) Predict the product. (4)
c) Arrange the compounds in the following sets in order of decreasing reactivity towards ring electrophilic substitution. (4)
i) C6H6, C6H5CI, C6H5NO2, C6H5CH3,
C6H5OH
ii) C6H5CH2CH2CH3, C6H5CH2COCH3, C6H5COCH2CH3
d) Draw the structure and write the uses of :- (4)
i) Saccharin
ii) Chloramine
2. a) Discuss the structure of Benzene with reference to :- (8)
i) The Kekule formula
ii) The resonance model
iii) The atomic molecular model
b) Benzene ordinarily undergo substitution in the ring rather than addition, although they are highly unsaturated". Justify this statement with suitable examples. (8)
3. a) Give two methods for preparation of Phenols laboratory. (4)
b) Draw the structure and write uses of :- (4)
i) Resorcinol
ii) Cresol
c) Discuss the mechanism of Reimer-Tiemann's reaction. (4)
d) How is it that Phenols are acidic in character while Alcohols are neutral? (4)
4. a) How will you convert Anilline to :- (4)
i) Benzylamine
ii) Benzoic acid
b) Why is an aromatic amine like Anilline or p-toluidine much weaker base than an Aliphatic Amine like methylamine? (4)
c) What is Hofmann rearrangement ? (4)
d) Write any two reactions of aniline those involves NH, group. (4)
5. a) How iodine value is determined? What is its significance? (4)
b) Write notes on following reactions of fats and oils :- (12)
i) Rancidification
ii) Drying
iii) Hydrolysis
iv) Hydrogenation
6. a) Draw the structure and write the uses of :- (4)
i) Naphthalene
ii) Diphenylmethane
b) Write Haworth synthesis for Anthracene. (4)
c) Discuss reduction and oxidation reactions of Naphthalene. (4)
d) Write any two electrophilic substitution reactions of Phenanthrene. (4)
7. a) Explain Baeyer Strain theory along with its limitations and modifications. (8)
b) Discuss the conformations of Cyclohexane. (4)
c) Identify the product :- (4)
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