IV Semester Examination May 2019
BACHELOR OF PHARMACY
Medicinal Chemistry - 1
(BP-402T)
Time :- 3 hrs. Marks :- 80
Answer any FIVE questions :-
1. Give the chemical names, structural formula and therapeutic uses of any four of the followings:- (4 × 4 = 16)
a) Dopamine
b) Ephedrine
c) Atenolol
d) Phenobarbital
e) Phenytoin
f) Thiopental Sodium
2. Classify the directly acting sympathomimetic drugs. Give their mode of action, synthesis of Phenylephrine and Salbutamol. (8 + 8 = 16)
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3. Discuss about any two of the following :-
a) Catabolism and biosynthesis of Acetylcholine
b) SAR of Benzodiazepines.
c) Phenothiazines as the antipsychotics.
4. Outline the synthesis of any four of the followings :- (4 × 4 = 16)
a) Neostigmine
b) Procyclidine hydrochloride
c) Carbamazepine
d) Mefenamic acid
e) Methadone hydrochloride
5. Discuss the following :- (4 × 4 = 16)
a) Bioisosterism
b) Factors affecting the drug metabolism
c) Role of partition coefficient in the biological activity
d) Phase I drug metabolism
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6. a) Write a detailed note on the beta adrenergic blockers. (8)
b) Classify the nartotic analgesics. Explain the SAR of morphine analogues. (8)
7. a) Give an account of solanaceous alkaloids and analogues as the cholinergic blocking agents. (8)
b) Write an exhaustive note on ultra-short acting barbiturates as the general anesthetics. (8)
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